Hollywood is hooked on it, and social media is fanning demand for the latest weight-loss ‘miracle’.

Over the summer I was lucky enough to be invited to a 60th birthday at which the after-dinner entertainment was a private performance by one of the UK’s leading male pop stars. More eye-popping than the actual show, though, was how incredible said star looked. He was a mere shadow of his former self, prancing around the stage in a silver catsuit. His secret? Semaglutide, or Ozempic as it is branded, a new diet drug that everybody – but everybody, darling, including one of the world’s most famous supermodels – is apparently taking.

Originally developed to treat type 2 diabetes, it is used off-label (for a purpose other than that for which it was licensed) in both the US and the UK to treat obesity. In research conducted by its billionaire manufacturer, the Danish-based pharmaceutical company Novo Nordisk, patients lost an average of 17 per cent of their overall body weight over 68 weeks. This compares with five to nine per cent for ‘old school’ anti-obesity drugs such as Metformin.

Only available in the UK on the NHS if you have type 2 diabetes, Ozempic can be obtained through a private doctor, and if you are willing to take it without medical supervision – not recommended by doctors (see panel) – you can get it online through various weight-lossprograms. It is sometimes taken in tablet form but more commonly as an injection.

Originally developed to treat type 2 diabetes, Semaglutide is used off-label. It has been branded as a new diet drug that everybody is apparently taking

Predictably, Hollywood has been aware of Ozempic for a lot longer than us—Variety magazine recently quipped that the drug deserved its own thank-you speech at the Emmys, as so many stars on the podium had obviously been taking it. Elon Musk raved about its more powerful sister drug, Wegovy, on Twitter; Kim Kardashian, it is hotly rumoured, used semaglutide to lose 16lb in order to fit into Marilyn Monroe’s dress for the Met Ball. On TikTok the hashtag #ozempic has had more than 285 million views.

Thanks to the hype, there has been a surge in demand, causing shortages on both sides of the Atlantic, with a backlash against influencers and celebrities hogging supplies ahead of desperate diabetes sufferers. Predictably, Big Pharma has come up with an alternative – tirzepatide (brand name Mounjaro), manufactured by Eli Lilly – but it has yet to be approved by the US Food & Drug Administration for weight loss.

Novo Nordisk has issued a statement to say its supplies will be replenished by the end of the year, but it hasn’t quelled anxiety. At least two middle-aged male friends of mine who started using it in September are getting themselves in a twist about being caught short before the holidays. As one private London GP remarked to me: ‘It’s like the H RT panic last spring.’

So what exactly is this drug? Semaglutide belongs to a class called GLP-1 agonists, which not only regulate blood sugar but, as was discovered about a decade ago, also mimic the gut hormones that regulate our appetites – the ones that tell the brain when we’re hungry or full. There are, of course, side effects: acid reflux, nausea, exacerbation of IBS symptoms and fatigue (but much less so than in earlier GLP-1 agonists such as Saxenda), as well as pancreatitis, gallstones and, in very high doses, it has caused thyroid tumors in rats. Meanwhile, when you stop using it the effect wears off immediately and in some cases it won’t work at all.

Celebrities are accused of hogging supplies ahead of desperate diabetes patients

‘I would describe semaglutide as an example of very smart science,’ says leading consultant endocrinologist Dr Efthimia Karra from her private practice off London’s Harley Street. But it is not a panacea for everyone. Around a fifth of users do not respond to it. This is because the human body favors weight gain, thus when you lose weight the body will do anything to revert to its highest BMI. The heavier you are the harder it is to lose weight. If a patient has made no progress in three months, I will take them off it.’

Banker’s wife Laura, a native New Yorker in her mid-50s who had hovered between decades, started using it in January. ‘The Paleo diet, 5:2, CBT, NLP, bootcamp, diet delivery services – I’ve tried them all,’ she says from the family home in Hampshire, ‘and I’ve always yo-yoed right back. After my last annual checkup I seriously contemplated giving up. Then my doctor suggested semaglutide.’

After only a month she noticed her clothes had become looser. From then on, the weight started dropping off. ‘The strange thing was, I wasn’t eating anything different. I just couldn’t physically have seconds any more, and the idea of ​​pudding after a full meal had lost its allure.’ Three months later, she is two stones lighter ‒ though occasionally she suffers heartburn if she eats too late at night or drinks alcohol ‒ and when we spoke in autumn, she was looking forward to losing another stone by Christmas.

‘There is a niggling voice that tells me it is both risky and lazy to take a drug to lose weight, and I worry that it will all pile on again if I stop taking it. But if it does, I will seriously consider taking it indefinitely.’

Private London GP Dr Martin Galy has been prescribing semaglutide for about a year to clients who cannot lose the weight they gained in menopause. He has seen it have a transformative effect, too, on much younger women who suffer from polycystic ovary syndrome. ‘PCOS sufferers are difficult to treat, and you can imagine how body image plays a very important part when it comes to self-esteem.’

But according to Tom Sanders, professor of nutrition and dietetics at King’s College London, it is not a magic bullet. Commenting on a study on semaglutide published in The New England Journal of Medicine in 2021, he says, ‘The challenge post-weight loss is to prevent a regain in weight,’ he wrote. It may prove to be useful in the short term, but ‘public health measures that encourage behavioral changes such as regular physical activity and moderating dietary energy intake are still needed’.

That said, given our rising national obesity statistics and the escalation in accompanying health issues such as heart failure, cancer and obstructive sleep apnoea clogging up hospital beds, we’re going to need something. Semaglutide may be the rich person’s drug today, but might it be approved for more widespread use? Only time will tell.

A GP’S HEALTH WARNING

Dr. Ellie Cannon on the risks of taking the drug for weight loss

Despite being a GP well versed in dishing out all sorts of medications, I find it shocking that anyone would choose to take a drug like Ozempic in an unsupervised way like this. All medications come with risks and side effects, even over-the-counter ones such as paracetamol. As a junior doctor I met a patient who ended up dying from liver failure after taking high street herbal tablets – she had been fooled by the promise of easy weight loss so disregarded potential side effects. But after a month of taking them she had irreversibly damaged her liver.

Ozempic – or semaglutide – is a wonder drug if you have diabetes. It’s a once-a-week injection that lowers glucose levels and slows digestion. It is licensed for use in type 2 diabetics when other medications don’t work and where weight loss is helpful. It is known to potentially cause pancreatitis (inflammation of the pancreas), visual and kidney problems as well as allergic reactions, so it is prescribed alongside strict medical supervision, with regular blood tests and assessments to monitor patients. I cannot understand why people would risk these side effects unless they truly need the medication. And the pitfalls are even greater if you are prepared to forego medical guidance completely by buying it online, with no one monitoring your blood, checking your medical history or changes in your health to see if you should be taking it at all.

The UK guidelines on the medication advise that common side effects include gallstones, burping, diarrhoea, dizziness, fatigue, abdominal pain, nausea and vomiting. This means as many as one in ten people using it will be affected. Of course, these are worth it when balanced against the benefits of the excellent diabetes treatment it can offer. But they hardly seem sensible for trivial weight loss that can be achieved in a safer, albeit slower way. A celebrity endorsement does not make it safe. No medication is risk-free when used in this unsupervised way.

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